I. Background of the invention
Since
February 2003 years, SARS infection has wreaks havoc in China, Hong Kong and many other countries in the world. Its effects had send repercussion throughout the entire
international society. The death
rate has been high and the Chinese and western medical social were quite
helpless about this. So China, Taiwan , Hong Kong, Singapore and Canada etc. were
listed on travel warning district by World Health Organization and pecuniary
loss surmount thousand a hundred million, Mankind is faced with death threat.
Knowing how to treat the SARS
virus infection had became the top most urgent matter in the Southeast Asia.
During this urgent and difficult period of time, the inventors had came up with
an innovative medical scheme to save lives, the newest of medical scheme is “Surface
Treatment of SARS-Infected Lungs”.
Due to the urgency
of saving lives, the draft was fax to the Hong kong chief
executive and Chinese leader on 15 May 2003. The English version was also
forwarded to “WHO-Padey”, “WHO-Liden” by Mey-Verme, Mrs Cnia (WDC) and the
leaders who were holding the Geneva meeting on 20 May 2003.
About the functions of
the lungs.
The
lungs mainly serve to redistribute the blood from the right ventricle via the
lung artery to various lung sub-arteries and capillary vessels in the alveoli,
thus achieving gas exchange introducing oxygen and releasing carbon dioxide.
Then the blood returns from the lung veins to the left atrium and mixed at a
certain proportion in the right ventricle. That is the big circulation of
oxygen-containing blood in the arteries providing energy for the body! (Fig.
1.)
Here
the medium for gas exchange is not special, just like pumping the air to the
bottom of a fish jar to produce bubbles and the oxygen enters the water by
rubbing against the external spherical surfaces of the rising bubbles. Our
alveoli work like the bubbles in the fish jar and have a large surface area for
air contact. The contact area of the dense alveolus tissues in the lungs is up
to 70 m2! Tiny blood vessels are spread over the surfaces of these
tissues to complete “gas exchange” or, in other words, pulmonary ventilation,
via distribution through the blood, interstitial layer and cells. That is the
basic idea of the lungs according to modern medicine.
On the medical history, sort of Lung diseases have been numerous. Tuberculosis used to be an infectious disease difficuit to cure. However, it can be cured 100% thanks to the discovery of multiple antibiotics. Infant pneumonia is also a common disease, not to speak of pneumococcus. This article describes how to treat SARS.
First, treatment by the traditional Chinese medicine. This method mainly relies on absorption function of theintestines and stomach, which impedes the development of the traditional Chinese medicine. Traditional Chinese prescriptions only help the intestines and stomach to share the burden of the liver, thereby improving only our immunity.
However,
the prevailing SARS cures at present are based on Western medicine. The Chinese
mainland advocates such antibiotics like tetracycline and erythromycin while Hong Kong regards ribavirin and steroid as effective
SARS-containing medicines, but in Canada, which had used Ribavirin for a long
time, has now stopped using it because it may have serious side effects.
However, no matter how
to, the antibiotics is being absorbed by the intestines
and stomach or injected via the veins, they cannot change the subject of the
method of transporting anti-bacterium factors in the blood. We call this method
blood therapy. Because,
many elements in the anti-bacterium factors cannot be
absorbed by the intestines and stomach, so the Western medicine takes the lead
by this therapy.
That
is why the medical circles are focusing on how to improve the efficiency of the
“anti-bacterium factors”.
But, as shown in Fig.2, if the injection point is found in the arteries of the lungs, then the “blood therapy” may become much more effective, as proven by the noticeable flow ratio of the artery and lung circulation. SARS-containing clinical practice is thus more effective. However, we want to point out that the efficiency direction of the “anti-bacterium blood therapy” of SARS is wrong.
As there is a need
to define air as an interface, so SARS infection is a kind of surface ulcerous infection. This is a
new medical definition, which is likely to revolutionize lung treatment! Therefore we use a familiar industrial
term “surface treatment” and to include a technique of supersonic treatment. This is like
applying purple liquid medicine to the ulcerous skin which is much more
effective than “blood therapy” using any antibiotic.
Up to this point, we can optimistically predict that once the “surface treatment”
technique which depends on various antibiotics recommended has found clinic
applications, then a SARS patients need only to go to the hospital to have
their lungs washed, and SARS will no longer be fatal. At the same time
it can also be effective for other pneumonia diseases.
Let’s
learn something about the physical properties of SARS before dealing with the
subject matter of this article—SARS treatment:
1. Fig. 3 is downloaded from the Internet. SARS virus is smaller than
50 nanometers. SARS virus has numerous crown-like developments, making it
absorptive. Overcoming such absorption is significant for the “surface
treatment” technique recommended in this article. When we contract bacterium-induced
faucitis, we just wet our throat with brine and the pain immediately subsides,
because some bacteria are “washed away” by brine, as proven by
observing under an electronic endoscope. This traditional inflammation relief
method through brine is well-known to all. Inspired by this idea, I think such a simple
method can also prevent SARS virus from entering the lungs through the mouth
and throat.
2. Super-small and super-light virus is visible only through an
electronic microscope and the 75-nm N95 standard respirators we use cannot keep
out SARS virus, so SARS virus spreads by means of the tiny water droplets and
dust particles in the air. In view of that, we can work out a series of
effective preventive measures like the “surface treatment” method recommended
in this article.
III. Five lung “surface treatment” methods
1. Antibiotic gasification and absorption;
2. Massage and sternutation;
3.
Taking out and sterilizing lung lobes;
4. Local quick freezing for sterilizing of lung lobes;
5. Injecting sterilizer into lung lobes.
The method of antibiotic gasification and absorption is not new. This method is effective at the early stage of infection and may serve as a preventive measure before and after medical operation. This method
presupposes that the antibiotic in question must be dissolvable in 37℃ water.
The method of massage and sternutation is more
suitably called physical therapy. It works like this:
pressing the alveoli by applying force on the lungs and detaching the virus from the cell wall of the alveoli. Facing the nose toward the sun may help to induce sternutation, which is recommendable at the early stage of infection or as a preventive measure. Therefore sunlight sternutation device will be popular on the market. Sternutation is the best exercise for the chest and lungs, and sneezing three times a day is good for senior
citizens. The benefits of such an exercise are hardly known but it is a good piece of news for people with weak
lungs. This method is just preventive but not effective in detaching the highly absorptive SARS virus.
Taking out and sterilizing lung lobes is not just a dream. It involves the invention and clinical application
of external blood oxygen adding device. This method includes liquid medicine submersion and temperature difference treatment, the latter being the latest medical concept not only suitable for lung patients but also for cancer patients and others. Further exploration of this method may help to replace antibiotic blood therapy
with this method:
a. External liquid medicine submersion is more flexible that internal liquid medicine submersion. There are a few or no Liquid medicines that do not damage alveolus tissues. However, an effective liquid medicine for lung lobe submersion will be more effective and attractive if combined with supersonic wave.
b.
What is temperature difference
treatment? The organs and virus
under treatment have difference physiological temperature
curves. Temperature difference effect is achieved by selecting a temperature
point which is fatal to viruses but from which the organs treated can revive.
It is not important whether this method is recorded in medical literature, but
the method proves simple, theessential point is the revival rate of the organ
under treatment. This is therefore a highly recommended method.
Local quick freezing and sterilizing of lung lobes is also based on temperature differences but technically it is an improvement from the above three discussions. Taking out lung lobes without cutting off
arteries and veins may minimize the damage
to the organ and inter-organ contact, making this method practical. While it is
difficult to carry out on Lungs, it is feasible for “semi-detached organs”
like. The root of the problem is that the quick-freezing equipment involved is
not as simple as an ammonia cyclic refrigerator. The clinic freezing device
must work in contact mode and is capable of lowering the temperature of an
organ of about 1 kg to -30-50℃ within 5 ~ 10 seconds. Many medical fields are gone up and
breakthroughs will rely on this kind of technical accomplishment that is made
in accordance to the trade circle of science and technology requirement.
Discussion 5
Injecting
sterilizer into lung lobes is the subject matter of surface treatment technique
of this article. I do not specialize in medicine but just a little medically
minded. Inspired by the idea of relieving oral and throat inflammation with
brine solution, I managed to find some suitable solvent and sterilizer, but it
has to undergo clinical test. But I’m sure that so long as some qualified
chemist proposes and there is an adequate range of solvents and sterilizers,
SARS will be overcome!
IIII. O1 Therapy for “surface treatment” of
the lungs
The sterilizing liquid injected into lung lobes is the surface treatment liquid for O1 therapy of the lungs.
The formal name for this liquid is Per
fluoro chemicals (PFC) and the sterilizer is ozone.
This method of introducing supersonic wave with sterilizing liquid may make SARS virus less absorptive
and quickly clear viruses in the lungs.
This new and practical therapy works like bombing the SARS virus with smart
cruise missiles. The missile is single oxygen (O1) separated from ozone, hence
“O1 Therapy”!
The effect of the regular
antibiotic therapy currently used is limited in that this therapy entails blood
exchange, and it is also limited by blood density. For example 50nm-minus SARS
virus is hidden in the middle layer that is inaccessible via the capillary
vessels, so the mortality rate of this “blood therapy” is still over 10%. The
“blood therapy” of Western medicine has reached its maximum potential. On the
contrary, “O1 therapy” is highly effective and is likely to reduce the death
rate to zero:
1.
Selection of PFE
solvent;
2.
Properties of ozone sterilizer;
3. Mixing of PFC and ozone;
4. Lung “surface
treatment” design flow;
5. Test with animal
lung;
6.
Special of operating table.
1.
Selection of [PFF] PFC solvent
PFC comes to our
mind when we select a liquid medium for cleaning alveoli. Clinical cases are
available for PFC breathing technique. We can rely completely on such
an effective sterilizer or antibiotic to kill SARS virus. PFC has the
characteristics:
1.
No color, taste or smell, not poisonous;
2.
Low surface tensile strength, not dissolvable in water or fat;
3. High dissolving
coefficient for oxygen and carbon dioxide, high density and low solubility,
higher dissolving coefficient for ozone;
4.
Volatile under indoor temperature and body temperature, does not
changeable into other matter via catabolism;
Per fluorine
chemical compound (Per fluoro chemicals, PFC) in the innovation medicine
application of this case is an important liquid-medium of oxygen for separate
out single oxygen-atom. The
member-type of PFC are C(5-18)F(12-38), the length of chain of member
structure was shown at the number of C, the number of C decides was inner
physical special quality, so the Boiling-Point was at 30℃-215℃. That is to say,
the Boiling-Point temperature with the number of C is in proportion. This
application seeks to first recommend C6F14 or C7F16, its purpose for
volatilizes as soon as possible then pouring into the lung after destroys the
germs. But in actual practice of clinical option, more considerations will have
to be taken into account, for instance, the level of ulcer by the germs
influence and the density of single oxygen-atom and so on; however, then the
other fluorine chemical compounds such as C5F9H3O while offering
swim-dissociating for the liquid medium of single oxygen-atom, which must emphasize the density effect of single oxygen-atom Depletion
Potential.
With the above features, PFC qualifies as a lung
surface treatment liquid.
It has a dynamic function. On the one hand, oxygen can pass through it to achieve
constant gas exchange in the lungs, and on the other hand, the liquid PFC can
permeate any alveoli, so that the O1 element in PFC can freely trace SARS
virus. The volatility of PFC ensures that no sequela will appear. What is more,
PFC can also clean the lungs of damaged cells, cell fragments resulting from
inflammation, and SARS virus residuals.
2. Characteristics of ozone sterilizer
1.
The molecule formula of ozone is O3,
which is an allotrope of high-energy oxygen and is dissolvable in water and
various liquid chemicals;
2. Low-density ozone is
colorless and smells like a special grass. It is blue at high temperature and
its density is 1.5 times that of air;
3. Ozone sterilizes by releasing single oxygen atom to oxidize and
damage the cell of the virus, leaving pure O2, which is beneficial to the
lungs;
4. Ozone dissolved in water sterilizes more forcibly and quickly, and
it is dissolvable in liquid PFC;
5. When the density of ozone exceeds a certain limit, its sterilizing
function is just a matter of seconds;
Therefore, ozone is a good choice as an alveoli sterilizer. The following figures are cited from world-recognized experiment documentation for ozone sterilizing.
Ozone sterilizing |
Density |
Time |
Types of viruses and pathogens |
Sterilizing efficiency |
10mg/m3 |
20 mins |
Type-B hepatitis
surface antigen (HbsAg) |
99.99% |
|
0.5ppm |
5 mins |
Type-A flu
virus |
99% |
|
0.13mg/L |
30
seconds |
Poliomyelitis
virus type I (PVI) |
100% |
|
40μg/L |
20
seconds |
Coliphage
ms2 |
98% |
|
0.25mg/L |
1
minute |
SA-H and human-wheel virus type 2 |
99.60% |
|
* 12.6mg/L |
4 minutes |
Coronaviridae |
100% |
|
4mg/L |
3 minutes |
HIV |
100% |
|
8mg/m3 |
10
minutes |
Mycoplasma,
Chlamydia, and other pathogens |
99.85% |
○ Red indicates every liter of lung
surface treatment solution contains 12.6mg ozone, which may serves as a reference
when we consider the test dosage of ozone.
3. Mixing of PFC and ozone
The working process-method of mixing the PFC and ozone are shown in Fig.4.
Fig.4-1 shows the ozone supply;Fig.4-2 shows the O3
Contriver;Fig.4-3 shows the PFC supply;Fig.4-4 shows
the passageway valve of liquid; Fig.4-5 shows the pump of gas and
liquid mixing;Fig.4-6 is the mix vessel; Fig.4-7 is the digital type tester of ozone density which has the
export-ability to brake of the working of the mixing pump;Fig.4-8 is the
controller of altitude of liquid and have the export-ability to the working of
the passageway valve of liquid.
[3]4.
Lung “surface treatment” flow
The treatment flow
takes the treatment for example of the right lung, while reserving the breath of
the left lung for the time being. The final purpose is to treat both lungs at
the same time. Process 3 can only be used only after process 4. Test it with
animal lung, before applying it on human. It must be noted that the test with
animal lung is intended to prove that it applies to process 3, the human body
treatment. The advantage of the reverse sequence is time saving.
a.
Surface treatment clinic (must be
professional anesthetist except for bio-chemical test of body energy): (Fig. [4] 5)
b.
Surface treatment clinic scheme
diagram: (Fig. 6)
[4]5.
Test with animal lung
Test with animal
lung includes two stages: test with one lung of the baby pig and test with both
lungs. This process simulates process 3, as specified below:
a. Inject pure PFC into three without virus influence of baby pig:
Baby
pig |
Pure PFC injection 10 mins |
Pure PFC injection 30 mins |
Pure PFC injection 120 mins |
||||||
|
Change of blood oxygen amount |
Heart
pulses |
Symptom
description |
Change of blood oxygen amount |
Heart
pulses |
Symptom
description |
Change of blood oxygen amount |
Heart
pulses |
Symptom
description |
1
|
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2
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b. Inject 12.6mg/L PFC into three virus-free pig to test its reaction to high-density ozone:
Baby pig |
Pure
PFC injection 10 mins |
Pure
PFC injection 30 mins |
Pure
PFC injection 120 mins |
||||||
|
Change
of blood oxygen amount |
Heart pulses |
Symptom description |
Change
of blood oxygen amount |
Heart pulses |
Symptom description |
Change
of blood oxygen amount |
Heart pulses |
Symptom description |
1
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2
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3
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c. Inject 25.2mg/L PFC into three virus-free pig to test its reaction to high-density ozone:
Baby pig |
Pure
PFC injection 10 mins |
Pure
PFC injection 30 mins |
Pure
PFC injection 120 mins |
||||||
|
Change of blood oxygen amount |
Heart pulses |
Symptom description |
Change of blood oxygen amount |
Heart pulses |
Symptom description |
Change of blood oxygen amount |
Heart pulses |
Symptom description |
1
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2
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3
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d. Inject 12.6mg/L PFC into three infected of baby pig to test its reaction to high-density ozone:
Baby pig |
Pure
PFC injection 10 mins |
Pure
PFC injection 30 mins |
Pure
PFC injection 120 mins |
||||||
|
Change of blood oxygen amount |
Heart pulses |
Symptom description |
Change of blood oxygen amount |
Heart pulses |
Symptom description |
Change of blood oxygen amount |
Heart pulses |
Symptom description |
1
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2
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3
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6. Important points in designing the operation table
-end-
Remark of Paper/WebPages:
1.
http://cms.3m.com/cms/US/en/2-68/iFcFiFM/view.jhtml
2.
http://www.vghtpe.gov.tw/~clinmed/ ( 89年12月期) [ Chinese]
Paper in
international journals:
3.
Jeng MJ, Kou YR*, Sheu CC, Hwang B. Effects
of Exogenous Surfactant Supplementation and Partial Liquid Ventilation on Acute
Lung Injury Induced by Wood Smoke Inhalation in Newborn Piglets. Crit Care Med
2003; 31:1166-1174
4.
Jeng MJ*, Yang SS, Wolfson MR, Shaffer
TH. Perfluorochemical (PFC) Combinations for Acute Lung Injury: An in Vitro and
in Vivo Study in Juvenile Rabbits. Pediatr Res 2003;53:81-88.
5.
Jeng MJ*, Oliver R, Wolfson MR,
Shaffer TH. Partial liquid ventilation: effect of initial dose and redosing
strategy in acute lung injury. Pediatr Crit Care Med 2002;3:163-171.
6.
Jeng MJ*, Kou YR, Sheu CC, Hwang B.
Effects of partial liquid ventilation with FC-77 on acute lung injury in
newborn piglets. Pediatr Pulmonol 2002; 33:12-21.
7.
Jeng MJ*, Trevisanuto D, Weis CM, Fox
WW, Wolfson MR, Shaffer TH. The role of ventilation strategy on
Perfluorochemical (PFC) evaporation from the lungs. J Appl Physiol 2001; 90:
1365-1372.
Trevisanuto D, Jeng MJ*, Weis CM, Fox WW, Wolfson MR, Shaffer TH. Positive end-expiratory pressure modulates perfluorochemical evaporation from the lungs. Biol Neonate 2003;84:53-58.